Genetic risk factor of COPD

Even if an individual has never smoked or been unprotected to pollutants for an extended period of time, they can still develop COPD. Alpha-1 Antitrypsin Deficiency (AATD) is the most commonly known hereditary hazard factor of COPD in emphysema. Alpha-1 Antitrypsin related COPD is caused by a deficiency of the Alpha-1 in the circulatory system. Without the Alpha-1 Antitrypsin protein, white platelets start to harm the lungs and lung deterioration occurs. The World Health Organization and the American Thoracic Society proposes that every individual determined to have COPD be tested for Alpha-1. Pulmonary Conferences also discusses about different types of genes which may be a cause of pulmonary diseases.

 

  • Alpha1-antitrypsin
  • Alpha1-antichymotrypsin
  • Cystic fibrosis transmembrane regulator
  • Vitamin D-binding protein
  • Alpha2-macroglobulin

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