Genetic risk factor of COPD


Even if an individual has never smoked or been unprotected to pollutants for an extended period, they can still develop COPDAlpha-1 Antitrypsin Deficiency (AATD) is the most commonly known genetic risk factor of COPD in emphysema. Alpha-1 Antitrypsin related COPD is caused by a deficiency of the Alpha-1 in the bloodstream. Without the Alpha-1 Antitrypsin protein, white blood cells begin to harm the lungs and lung deterioration occurs. The World Health Organization and the American Thoracic Society suggests that everyone determined to have COPD be tested for Alpha-1Pulmonary Conferences also discusses about different types of genes which may be a cause of pulmonary diseases.


  • Alpha1-antitrypsin
  • Alpha1-antichymotrypsin
  • Cystic fibrosis transmembrane regulator
  • Vitamin D-binding protein
  • Alpha2-macroglobulin

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